Published: Fri, December 01, 2017
Health Care | By Alberto Manning

Migraine drug makes people have fewer 'migraine days'

Migraine drug makes people have fewer 'migraine days'

"I can have anywhere from 15 to 18 headaches per month, and probably five of those days are migraines", but that dropped 40 percent on the drug, she said.

Many study leaders work for or have other financial ties to the drugmakers, and the companies helped analyze results.

About 1,000 patients were given monthly shots for three months: One third got the drug each time, another third got the drug the first time and then dummy shots the next two times, and the rest got dummy shots each time.

"We are very proud that the fremanezumab chronic migraine results are the first Phase III CM anti-CGRP therapy data published, especially in such a prestigious and well-renowned peer-reviewed journal".

Average reductions of one or two days a month are modest, but "there are some patients who have had a complete response - they become headache-free", Hershey said. They said the new drug managed to cut the length of migraine attacks in half.

A quarter of patients who received placebo injection also reported a reduction in symptoms.

Patients with headaches on more than half of the days each month have chronic migraines. Those on low dose Erenumab had a reduction of 3.2 days of migraine on average. In contrast, the placebo group saw a 2.5-day reduction in headache days per month. After the drug was administered, 41 percent of those who received the monthly injection showed a reduction of symptoms by half.

Aimovig also showed superiority in the secondary endpoint with a significant reduction in the number of days per month a rescue medication was needed compared to placebo: 1.6 days for 140mg, 1.1 days for 70mg, and 0.2 days for the placebo group (P 0.001).

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Those receiving the drug reported migraines having a reduced impact on their everyday lives, being able to better complete activities such as getting ready for the day, doing household chores or activities requiring concentration.

Both these drugs are produced in the laboratory and act by mimicking the body's immune cells.

Lipton noted that there has been a "staggering record of success" in regards to the monoclonal antibody class of medicines.

Erenumab is an antibody that alters signaling pathways in the brain called calcitonin gene-related peptide or CGRP in order to prevent migraine attacks.

Preclinical evidence suggests that, during a migraine, activated primary sensory neurons (meningeal nociceptors) in the trigeminal ganglion release CGRP from their peripherally projecting nerve endings located within the meninges. Blocking this protein could help reduce the severity and frequency of migrains speculate researchers.

In a discussion with BBC, Professor Peter Goadsby - leader of the erenumab trials - stated that "It's a huge deal because it offers an advance in understanding the disorder and a designer migraine treatment..."

The World Health Organisation ranks migraines as the 7th most disabling disease worldwide and classifies severe attacks as among the most disabling illnesses, comparable to dementia, quadriplegia and active psychosis.

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